If you are worried that some programs might not run on the new M1 chip that Apple is using to replace Intel processors, you generally don’t need to worry.
Apple runs a translation software called Rosetta 2 on the new Macs, which simply translates programs designed for Intel processors. Nevertheless, it is nice to hear large manufacturers of comprehensive software packages explicitly mention again that their software runs without problems on macOS Big Sur, the first macOS version for Apple Silicon Macs.
Microsoft is one of them, who confirm this in a press release. It is also mentioned that work is already underway to further develop Microsoft 365 and Office, so that it will run natively on the M1 chip and all following ones.